高翔实验室

联系方式

办公室：025-58641598

实验室：025-58641511

研究所邮箱：gaoxiang at?nicemice.cn

P I 简介
科 ??? 研
文 ??? 章
项 ??? 目
成 ??? 员

高翔博士，1994年获美国Thomas Jefferson University发育生物学与解剖学专业博士学位，南京大学模式动物研究所创始人。2000年受聘为南京大学教授，2002年受聘为博士生导师及教育部长江奖励计划特聘教授，2008年获国家杰出青年科学基金。现任医药生物技术国家重点实验室主任。

A. Research papers (*Correspondence author)

1. ? ?Wang Q, Tang J, Jiang S et al. Inhibition of PPARgamma, adipogenesis and insulin sensitivity by MAGED1. J Endocrinol. 2018. In press.

2. ? ?Rozman J, Rathkolb B, Oestereicher MA et al. Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nature Comm. 2018;9:288.

3. ? ?Luan XR, Chen XL, Tang YX et al. CRISPR/Cas9-Mediated Treatment Ameliorates the Phenotype of the Epidermolytic Palmoplantar Keratoderma-like Mouse. Mol Therapy Nucleic Acids. 2018;12:220-228.

4. ? ?Lin Z, Liu F, Shi P et al. Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Therapy. 2018;9:47.

5. ? ?Chen Q, Shi P, Wang Y et al. GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biology. 2018.

6. ? ?Lin Z et al (2018) Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther, 9(1): 47~47.

7. ? ?Lai et al (2018) Haploinsufficiency of hnRNP U changes activity pattern and metabolic rhythms. Am J Path, 188(1):173-183.

8. ? ?Rozman J et al (2017) Identification of novel genetic elements in metabolism by high-throughput mouse phenotyping. Nature Comm, in press.

9. ? ?Zou JH et al (2017) CD4+ T cells memorize obesity and promote weight regain. Cell Mol Immunol, online.

10. ?Meehan TF et al (2017) Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet. 49:1231-1238.

11. ?Song AY et al (2017) JMJD3 is crucial for female AVPV RIP-Cre neuron controlled kisspeptin-estrogen feedback loop and reproductive function. Endocrinol, 158:1798-811 Editorial: A shot in the dark exposes more trees in the forest. By Kurian JR, Endocrinol, 158:1572-4.

12. ?Li F et al (2017) The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner. Nat Comm. 7:13839.

13. ?Karp N et al (2017) Prevalence of sexual dimorphism in mammalian phenotypic traits. Nature Comm, 8:15475.

14. ?Wang X, Li MM, Zhao J, Li S, MacDonald MR, Rice CM, Gao X, Gao G* (2016) Sindbis Virus Can Exploit a Host Antiviral Protein To Evade Immune Surveillance. J Virol, 90:10247-10258.

15. ?Tang A, Shi P, Song A, Zou D, Zhou Y, Gu P, Huang Z, Wang Q, Lin Z*, Gao X* (2016) PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte. Cell Cycle, 15:1450-1461

16. ?Lyu YS, Shi PL, Chen XL, Tang YX, Wang YF, Liu RR, Luan XR, Fang Y, Mei RH, Du ZF, Ke HP, Matro E, Li LE, Lin ZY, Zhao J, Gao X, Zhang XN* (2016) A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy. Mol Thera Nuc Acids, 5:e299.

17. ?Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega RB, Zhu MS, Kelly DP, Gao X, Gan Z* (2016) Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med, 8:1212-1228.

18. ?Lai SS, Zhao DD, Cao P, Lu K, Luo OY, Chen WB, Liu J, Jiang EZ, Yu ZH, Lee G, Li J, Yu DC, Xu XJ, Zhu MS, Gao X*, Li CJ*, Xue B* (2016) PP2Acalpha positively regulates the termination of liver regeneration in mice through the AKT/GSK3beta/Cyclin D1 pathway. J Hepatol, 64(2):352-360.

19. ?Jiang S, Wang Q, Huang Z, Song A, Peng Y, Hou S, Guo S, Zhu W, Yan S, Lin Z*, Gao X* (2016) Gastric Bypass Surgery Reverses Diabetic Phenotypes in Bdnf-Deficient Mice. Am J Pathol, 186:2117-2128.

20. ?Jiang H, Shi H, Sun M, Wang Y, Meng Q, Guo P, Cao Y, Chen J, Gao X, Li E, Liu J* (2016) PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense. J Immunol, 197:2880-2890.

21. ?Hou S, Xian L, Shi P, Li C, Lin Z*, Gao X* (2016) The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice. Sci Rep, 6:26735.

亚游app官网下载|开户22. ?Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA (2016) High-throughput discovery of novel developmental phenotypes. Nature, 537:508-514.

23. ?Zou Q, Wang X, Liu Y, Ouyang Z, Long H, Wei S, Xin J, Zhao B, Lai S, Shen J, Ni Q, Yang H, Zhong H, Li L, Hu M, Zhang Q, Zhou Z, He J, Yan Q, Fan N, Zhao Y, Liu Z, Guo L, Huang J, Zhang G, Ying J*, Lai L*, Gao X* (2015) Generation of gene-target dogs using CRISPR/Cas9 system. J Mol Cell Biol, 7:580-583.

24. ?Zou J, Xiong X, Lai B, Sun M, Tu X, Gao X* (2015) Glucose metabolic abnormality is associated with defective mineral homeostasis in skeletal disorder mouse model. Sci China Life Sci, 58:359-367.

25. ?Yu P, Zhang Y, Li C, Li Y, Jiang S, Zhang X, Ding Z, Tu F, Wu J, Gao X, Li L* (2015) Class III PI3K-mediated prolonged activation of autophagy plays a critical role in the transition of cardiac hypertrophy to heart failure. J Cell Mol Med, 19:1710-1719.

26. ?Yang J, Lai B, Xu A, Liu Y, Li X, Zhao Y, Li W, Ji M, Hu G, Gao X, Gao J* (2015) Maged1 co-interacting with CREB through a hexapeptide repeat domain regulates learning and memory in mice. Mol Neurobiol, 51(1):8-18.

27. ?Xian L, Hou S, Huang Z, Tang A, Shi P, Wang Q, Song A, Jiang S, Lin Z, Guo S, Gao X* (2015) Liver-specific deletion of Ppp2calpha enhances glucose metabolism and insulin sensitivity. Aging, 7:223-232.

28. ?Tao W, Wu J, Xie BX, Zhao YY, Shen N, Jiang S, Wang XX, Xu N, Jiang C, Chen S, Gao X, Xue B*, Li CJ* (2015) Lipid-induced Muscle Insulin Resistance Is Mediated by GGPPS via Modulation of the RhoA/Rho Kinase Signaling Pathway. J Biol Chem, 290:20086-20097.

29. ?Sun Y, Wang C, Hao Z, Dai J, Chen D, Xu Z, Shi D, Mao P, Teng H, Gao X, Hu Z, Shen H, Jiang Q* (2015) A common variant of ubiquinol-cytochrome c reductase complex is associated with DDH. PloS One, 10:e0120212.

30. ?Sun Y, Deng W, Geng L, Zhang L, Liu R, Chen W, Yao G, Zhang H, Feng X, Gao X, Sun L* (2015) Mesenchymal stem cells from patients with rheumatoid arthritis display impaired function in inhibiting Th17 cells. J Immunol Res, 2015:284215.

31. ?Shi P, Tang A, Xian L, Hou S, Zou D, Lv Y, Huang Z, Wang Q, Song A, Lin Z, Gao X* (2015) Loss of conserved Gsdma3 self-regulation causes autophagy and cell death. Biochem J, 468:325-336.

32. ?Qu Z, Wang X, Liu D, Gao X, Xu Y* (2015) Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice. Sci China Life Sci, 58:368-372.

33. ?Qi X, Gao X* (2015) Towards a better understanding of mouse and human diseases-International Mouse Phenotyping Consortium. Sci China Life Sci, 58:392-395.

34. ?Miller M, Beppu A, Rosenthal P, Pham A, Das S, Karta M, Song DJ, Vuong C, Doherty T, Croft M, Zuraw B, Zhang X, Gao X, Aceves S, Chouiali F, Hamid Q, Broide DH*(2015) Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M. J Immunol, 195:3546-3556.

35. ?Liu R, Li X, Zhang Z, Zhou M, Sun Y, Su D, Feng X, Gao X, Shi S, Chen W, Sun L* (2015) Allogeneic mesenchymal stem cells inhibited T follicular helper cell generation in rheumatoid arthritis. Sci Rep, 5:12777.

36. ?Li L, Zeng Z, Qi Z, Wang X, Gao X, Wei H, Sun R, Tian Z* (2015) Natural Killer Cells-Produced IFN-gamma Improves Bone Marrow-Derived Hepatocytes Regeneration in Murine Liver Failure Model. Sci Rep, 5:13687.

37. ?Hou H, Zheng K, Wang G, Ikegawa S, Zheng M, Gao X, Qin J, Teng H, Jiang Q* (2015) Influence of intra-articular administration of trichostatin a on autologous osteochondral transplantation in a rabbit model. BioMed Res Int, 2015:470934.

38. ?Gu Y, He Y, Zhang X, Shi Y, Yang Q, Yu L, Sun Z, Zhang H, Wang J, Gao X, Wang J* (2015) Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice. Mol Rep Devel, 82:475-488.

39. ?Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du J, Li CJ, Gan ZJ, Gao X, Chen HQ, Zhu MS* (2015) Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. PNAS USA, 112:13627-13632.

40. ?Gao X* (2015) Model animals and their applications. Sci China Life Sci, 58:319-320.

41. ?Gao M, Wang X, Zhang X, Ha T, Ma H, Liu L, Kalbfleisch JH, Gao X, Kao RL, Williams DL, Li C* (2015) Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression. J Immunol, 195:672-682.

42. ?Dong D, Li L, Gu P, Jin T, Wen M, Yuan C, Gao X, Liu C, Zhang Z*（2015） Profiling metabolic remodeling in PP2Acalpha deficiency and chronic pressure overload mouse hearts. FEBS Lett, 589:3631-3639.

43. ?Huang Z, Ruan H, Zhang Z, Chen W, Lin Z, Zeng H, Gao X (2014) Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in mice. The American journal of pathology 184: 122-132.

44. ?Qi X, Xu JY, Gu PY, Yang X, Gao X (2014) PTEN in smooth muscle cells is essential for colonic immune homeostasis. International Journal of Biochemistry & Cell Biology 53: 108-114.

45. ?Huang Z, Ruan H-B, Xian L, Chen W, Jiang S, Song A, Wang Q, Shi P, Gu X, Gao X (2014) The stem cell factor/Kit signalling pathway regulates mitochondrial function and energy expenditure. Nature communications 5: 4282.

46. ?Lin Z, Zhang Y, Gao T, Wang L, Zhang Q, Zhou J, Zhao J. Homologous recombination efficiency enhanced by inhibition of MEK and GSK3b. Genesis 2014 (Accepted)

47. ?Shi GS, Xing LJ, Liu ZW, Qu ZP, Wu X, Dong Z, Wang XH, Gao X, Huang ML, Yan J, Yang L, Liu Y, Ptacek LJ, Xu Y (2013) Dual roles of FBXL3? tinhe mammalian circadian feedback loops are important for period determination and robustness of the clock. PNASUSA, in press

48. ?Wang XH, Ha TZ, Liu L, Zou JH,? Zhang X, Kalbfleisch J, Gao X, Williams D, Li CF (2013) Increased expression of microRNA-146a decreases myocardial ischemia/reperfusion injury. Cardiovas Res. In press

49. ?Song Y, Xu JL, Li YF, Jia CS, Ma XW, Zhang L, Xie XJ, Zhang Y, *Gao X, *Zhang YY, *Zhu DH (2012) Cardiac ankyrin repeat protein attenuates cardiac hypertrophy by inhibition of ERK1/2 and TGF-b signaling pathways. Plos One, in press

50. ?Zhang Q, Li YF, Zhang L, Yang N, Meng J, Zuo PP, Zhang Y, Chen J, Wang L, *Gao X, *Zhu DH (2012) E3 ubiquitin ligase RNF13 involves spatial learning and assembly 3 of the SNARE complex. Cell Mol Life Sci. in press

51. ?Cao ZJ, Ren DY, Ha TZ, Liu L, Wang XH, Kalbfleisch J, Gao X, Kao R, Williams D, Li CF (2012) CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: involving activation of PI3K/Akt signaling. BBA-Molecular Basis of Disease. In press

52. ?Gao M, Ha TZ, Zhang X, Liu L, Wang XH, Kelley J, Singh K, Kao R, Gao X, Williams D, Li CF (2012) Toll-like receptor 3 plays a central role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med. 40:2390-99

53. ?Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L, Zhang X (2012) Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell. 149:1549-64.

54. ?Li Y, Li SY, Hoshino M, Ishikawa R, Kajiwara C, Gao X, Zhao YF, Ishido SS, Udono H, Wang JY (2012) HSP90α deficiency does not affect Ig gene hypermutation and class switch but causes enhanced MHC class II antigen presentation. Int Immunol, in press

55. ?Jiang X, Zhou Y, Xian L, Chen WQ, *Gao X (2012) The mutation in Chd7 causes misexpression of Bmp4 and developmental defects in telencephalic midline. Am J Path, in press

56. ?Yang H, Shi LY, Wang BA, Liang D, Zhong CQ, Liu W, ?Nie YZ, Liu J, Zhao J, Gao X, Li DS, Xu GL, Li JS (2012) Generation of Genetically Modi?ed Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells. Cell, in press

57. ?Yang Q, He X, Yang L, Zhou ZY, Cullinane AR, Wei AH, Zhang Z, Hao ZH, Zhang AL, He M, Feng YQ, Gao X, Gahl WA, Huizing M, Li W (2012) The BLOS1 interacting protein KXD1 is involved in the biogenesis of lysosome-related organelles. Traffic, in press

58. ?Xu JY, Qi X, Gong JF, Yu MY, Zhang FX, Sha HB, Zhang X, *Gao X. Fstl1 antagonizes BMP signaling and regulates ureter development. PLoS One,? in press

59. ?Liu Y, Zhou DZ, Zhang F, Tu YY; Yulei Xia; Hui Wang; Ben Zhou; Yi Zhang; Jingxia Wu; Xiang Gao, He ZS, Zai QW (2012) Liver Patt1 deficiency protects male mice from age-associated but not high-fat diet-induced hepatic steatosis. J Lipid Res. 53: 358-367

60. ?Zhou Y, Jiang X, Gu PY, Chen WQ, Zeng XS, *Gao X (2012) Gsdma3 mutation causes bulge stem cell depletion and alopecia mediated by skin inflammation. Am J Path, 180: 763-774

61. ?Gu PY, Qi X, Zhou Y, Wang Y, *Gao X （2012）Generation?of?Ppp2ca?and?Ppp2cb?conditional?null?alleles?in?mouse. Genesis, 00:1–9

62. ?Lin ZY, Perez P, Lei D, Xua J, Gao X, Bao JX (2011) Two-phase analysis of molecular pathways underlying iPS cell induction. Stem Cells, 29:1963-74

63. ?Yang WW, Xia Y, Ji HT, Zheng YH, Liang J, Huang WH, Gao X, Aldape K, Lu ZM (2011) Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature, 478: 118-122

64. ?Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Y, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W, Liu Y (2011) PKA phosphorylation couples hepatic inositol-requiring enzyme 1α to glucagon signaling in glucose metabolism. Proc Natl Acad SciUSA. 108:15852-7

65. ?Wu D, Qiu Y, Gao X, Yuan XB, Zhai Q (2011) Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function. PLoS ONE 6: 217590

66. ?Chen L, Zheng SZ, Sun ZG, Wang AY, Huang CH, Punchard NA, Huang SL, Gao X, Lu Y (2011) Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity. Cancer Chemother. Pharmacol. 68: 170

67. ?Li YQ, GaoX Wang JY (2011) Comparison of two POLQ mutants reveals that a polymerase-inactive POLQ retains significant function in tolerance to etoposide and γ-irradiation in mouse B cells. Genes to Cells, 16:973-83

68. ?Yu X, Shen N, Pan FY, Liu C, Gao Q, Gao X,? Xue B, Li CJ (2011) Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice. EMBO J. 30: 3754 - 3765

69. ?Shen N, Yu X, Pan FY, Gao X, Xue B, Li CJ (2011) An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism. J Biol Chem. 286:14508-15

70. ?Wang XH, Gao X, Xu Y (2011) MAGED1: Molecular insights and clinical implications.? Annals of Medicine, 43:347-355

71. ?Geng Y, Dong YY, Yu MY, Zhang L, Yan XH, Sun JX, Qiao L, Geng XH, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang DH, Ning W(2011) Follistatin-like 1 is a BMP 4 signaling antagonist in controlling mouse lung development. PNAS 108:7058-7063

72. ?Lin Xu L, Wang ZX, Xiong XW, Gu XX, *Gao X, *Gao X (2011) Identification of a novel point mutation of mouse Atp2b2 induced by N-ethyl-N-nitrosourea mutagenesis. Exp Animals 60:1 71-78

73. ?Li KC, Zhang FX, Li CL, Wang F, Yu MY, Zhong YQ, Zhang KH, Lu YJ, Wang Q, Ma XL, Yao JR, Wang JY, Lin LB, Han M, Zhang YQ, Kuner R, Xiao HS, Bao L, *Gao X, *Zhang X (2011) Follistatin-like 1 suppresses sensory afferent transmission by activating Na+,K+-ATPase. Neuron. 69:974-87. Spotlight paper

74. ?Chen WQ, Gu PY, Jiang X, Ruan HB, Li CJ, *Gao X (2011) Protein phosphatase 2A catalytic subunit alpha maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway. Am J Path. 178:2333-43

75. ?Lei M, Gao X, Yang L, Yang T, Lian X (2011) Gsdma3 gene is needed for the induction of apoptosis-driven catagen during mouse hair follicle cycle. Histochem Cell Biol, 136:335-343

76. ?Xiao F, Huang Z, Li HK, Yu JJ, Wang CX, Chen SH, Meng QS, Cheng Y, Gao X, Li J, Liu Y, Guo FF（2011） Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes, 60:746

77. ?Jiang P, Du WJ, Wang XW, Mancuso A, Gao X, Wu M, Yang XL (2011) p53 regulates the pentose phosphate pathway. Nature Cell Biol, 13:310

78. ?Jin ZX, Sun R, Wei HM, Gao X, Chen YY, Tian ZG (2011) Accelerated liver fibrosis in HBV transgenic mice: Involvement of NKT cells. Hepatology, 53:219-29

79. ?Zhou H, Qian J, Li C, Li J, Zhang X, Ding Z, Gao X, Han Z, Cheng Y, Liu L (2011) Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3K-dependent mechanism. Cardiovasc Res 89:109-18

80. ?Zhang CQ, Wang J, Hua X, Fang JG, *Zhu HQ, *Gao X (2011) A mutation degree model for the identification of transcriptional regulatory elements. BMC Bioinformatics 12:262

81. ?Xiao F, Wang HX, Fu XR, Li YF, Ma KW, Sun LG, Gao X, Wu Z. (2011) Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration, Cell Research, 21:350-64

82. ?Cao YH, Li H, Sun Y, Chen XF, Liu HF, Gao X, Liu XL (2010) Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression. Eur J Immunol, 40:3198-209

83. ?Chang Z, Zhang Q, Feng Q, Xu J, Teng T, Luan Q, Shan C, Hu Y, Hemmings BA, Gao X, Yang Z (2010) Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation. Dev Biol. 347:384-91

84. ?Chen WQ, Li? CF, Jiang? X,? Ruan HB, Qi? X, Liu? L, Zhao? QS, *Gao X (2010) Over-expressing dominant negative MyD88 induces cardiac dysfunction in transgenic mice. Chinese Sci Bull 55:3569-3575

85. ?Gong J, Xu J, Zhu W, Gao X, Li N, Li J. (2010) Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation. Clin Immunol. 136:245-56

86. ?Yang L, Zhao LY, Gan ZJ, He ZX, Xu JY, Gao X, Wang XR, Han WP, Chen LY, Xu T, Li WJ, Liu Y (2010) Deficiency in RNA Editing Enzyme ADAR2 Impairs Regulated Exocytosis. FASEB J,? 24: 3720-32

87. ?Zhang X, Min XY, Li CF, Benjamin IJ, Qian B, Zhang XJ, Ding ZN, Gao X, Yao YZ, Ma YJ, Cheng YL and Liu L (2010) Involvement of reductive stress in the cardiomyopathy in transgenic mice with cardiac-specific overexpression of heat shock protein 27. Hypertension, 55:1412-7.? Comment in: Hypertension. 55:1299-300

88. ?Ha TZ, Hu YL, Liu L, Lu C, McMullen JR, Kelley J, Kao RL, Williams DL, Gao X, Li CF (2010) TLR2 ligands induce cardioprotection against ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism. Cardiovas Res, 87:694-703

89. ?Ji JF, Wang ZY, Shi DQ, Gao X, Jiang Q (2010) Pathologic changes of Achilles tendon in leptin-deficient mice. Rheumatology international?30:489-93

90. ?Wang X, Tang J, Xing L, Shi G, Ruan HB, Gu X, Liu ZW, Wu X, *Gao X, *Xu Y (2010) Interaction of MAGED1 with nuclear receptors affects circadian clock function. EMBO J, 29:1389-400

91. ?Wen J, Chiang YJ, GaoC, XueH, Xu JY, Ning YH, Hodes RJ, Gao X, Chen YG (2010) Loss of Dact1 disrupts PCP signaling by altering Dishevelled activity and leads to posterior malformation in mice.? J Biol Chem, 285:11023-30

92. ?Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y. (2010) A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal. 3:ra7.

93. ?Ha T, Lu C, Liu L, Hua F, Hu Y, Kelley JL, Singh K, Kao RL, Kalbfleisch J, Williams DL, Gao X, Li C.(2010) TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase dependent mechanism.? Am J Physiol, Heart Circ Physiol. 298:H984-91

94. ?Guo XL, Ruan HB, Li Y, Gao X, Li W (2010) Identification of a novel nonsense mutation on the Pax3 gene in ENU-derived white belly spotting mice and its genetic interaction with c-Kit. Pigment Cell Melanoma Res. 23:252-62

95. ?Zhang WC, Peng YJ, Zhang GS, He WQ, Qiao YN, Dong YY, Gao YQ, Chen C, Zhang CH, Li W, Shen HH, Ning W, Kamm KE, Stull JT, Gao X, Zhu MS (2010)Myosin light chain kinase is necessary for tonic airway smooth muscle contraction. J Biol Chem, 285:5522-31

96. ?Xu F, Li K, Tian M, Hu P, Song W, Chen J, Gao X, Zhao QS (2009) N-CoR is required for patterning the anterior–posterior axis of zebrafish hindbrain by actively repressing retinoid signaling. Mech Devel. 126:771-80

97. ?You WJ, Min XY, Zhang XJ, Qian B, Pang SS, Ding ZN, Li CF, Gao X, Di RM, Cheng YL, Liu L (2009) Cardiac-specific expression of heat shock protein 27 attenuated endotoxin-induced cardiac dysfunction and mortality in mice through a PI3K/Akt-dependent mechanism. Shock 32:108-17.

98. ?Yao Y, Zhang F, Wang LS, Zhang G, Wang Z, Chen JM and Gao X (2009) Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction. J Biomed Sci, 16:74.

99. ?Mori H, Ouchida R, Hijikata A, Kitamura H, Ohara O, Li Y, Gao X, Yasui A, Lloyd RS, Wang JY (2009) Deficiency of the oxidative damage-specific DNA glycosylase NEIL1 leads to reduced germinal center B cell expansion. DNA Repair, 8:1328-1332

100.Masuda K, Ouchida R, Li YQ, Gao X, Mori H, Wang JY (2009) A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during immunoglobulin gene hypermutation. J Immunol. 183:1846-50

101.Wang ZJ, Zhang FM, Wang LS, Yao Y, Zhao Q, Gao X (2009) Lipopolysaccharides can protect mesenchymal stem cells (MSCs) from oxidative stress-induced apoptosis and enhance proliferation of MSCs via Toll-like receptor(TLR)-4 and PI3K/Akt. Cell Biol Int. 33:665-74

102.Zheng Y, Xia Y, Hawke D, Halle M, Tremblay M, Gao X, Zhou X, Aldape K, Cobb M, Xie K, He J, and Lu Z (2009) FAK phosphorylation by ERK primes Ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell. 35:11-25.

103.Zhao J, Ding J, Li YQ, Ren KQ, Sha JH, Zhu MS, *Gao X (2009) HnRNP U mediates the long-range regulation of Shh expression during limb development. Hum Mol Genet. 18:3090-7

104.Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W, Liu Y (2009) Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology. 49:1166-75

105.Lin C, Jiang X, Dai Z, Guo X, Weng T, Wang J, Li Y, Feng G, *Gao X, *He L (2009) Sclerostin mediates bone response to mechanical unloading via antagonizing Wnt/?-catenin signaling. J Bone Miner Res, 24:1651-1661, selected for Faculty of 1000 Medicine as “Must Read”

106.Ding J, Gao Y, Zhao J, Yan H, Guo SY, Zhang QX, Li LS, *Gao X（2009）Pax6 haploinsufficiency causes abnormal metabolic homeostasis by down-regulating GLP-1 in mice. Endocrinology, 150(5):2136-44

107.Wen JH, Chen YY, Song SJ, Ding J, Gao Y, Hu QK, Feng RP, Liu YZ, Ren GC, Zhang CY, Hong TP, *Gao X, and *Li LS ?(2009) Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). Diabetologia, 52:504-13.

108.Wang X, Zhang Y, Xiao G, Gao X, Liu XL (2009) c-Fos enhances survival of thymocytes during positive selection by upregulating Bcl-2.? Cell Res. 19:340-7

109.Ding XF, Luo C, Zhou JL, Zhong YL, Hu X, Zhou FL, Ren KQ, Gan L, He A, Zhu JL, Gao X, Zhang J (2009) The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation. J Cell Biochem 106:285-95.

110.Liu ZP, Zhang CL, Li Y, Wu ZY, Qian F, Yang XL, He WJ, Gao X, Guo Z (2009) A Zn2+ fluorescent sensor derived from 2-(pyridin-2-yl)benzoimidazole with ratiometric sensing potential. Organic letters. 11:795-8

111.Qian F, Zhang CL, Zhang Y, He WJ, Gao X, Hu P, Guo ZJ (2009) Visible light excitable Zn2+ fluorescent sensor derived from an intramolecular charge transfer fluorophore and its in vitro and in vivo application. Journal of the American Chemical Society. 31:1460-8

112.Zhang YF, Li H, Wang XM, Gao X, Liu XL (2009) Regulation of T cell development and activation by creatine kinase B. PLoS ONE. 4:e5000

113.Chen H, Jin H, Du CY, Gu PY, Wang CY, Zhang QX, Gao X（2008）Establishment of transgenic mice expressing SV40T in parietal cells. Acta Anatomica Sinica 39: 699-702

114.Ding XF, Luo C, Ren KQ, Zhang J, Zhou JL, Hu X, Liu RS, Wang Y, *Gao X, *Zhang J (2008) ?Characterization and expression of a human KCTD1 gene containing the BTB domain, which mediates transcriptional repression and homomeric interactions. DNA and Cell Biology 27: 257-265

115.Ha TZ, Hua F, Liu X, Ma J, McMullen JR, Shioi T, Izumo S, Kelley J, Gao X, Browder W, Williams DL, Kao RL, Li CF (2008) Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism. Cardiovascular Research. 78:546-53

116.Zeng H, Chen Y, Yu M, Xue L, Gao X, Morris SW, Wang D, Wen R (2008)TCR-mediated activation of CD4+CD44hi T cells bypasses Bcl10： An implication of differential NF-?B dependence of na?ve and memory T cells during TCR-mediated responses.? J Biol Chem, 283:24392-9

117.Wang XM, Xiao G, Zhang YF, Wen XM, Gao X, Okada S, Liu X (2008) Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition Nature Immunology,? 9(7):794-801

118.He WQ, ?Peng YJ, Zhang WC, Lv N, Tang J, Chen C, Zhang CH, Gao S, Chen HQ, Zhi G, Feil R, Kamm KE, Stull JT, *Gao X, *Zhu MS (2008) Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology, 135:610-20.

119.Liang D, Zhang M, Bao J, Zhang L, Xu X, Gao X, Zhao QS (2008) Expressions of Raldh3 and Raldh4 during zebrafish early development.? Gene Expression Pattern, 8:248-53

120.Xiong?X, Qi X, Ge XM, Gu P, Zhao J, Zhao QS, *Gao X.(2008) A novel Phex mutation with defective glycosylation causes hypophosphatemia and rickets in mice. J Biomed Sci, 15:47-59

121.Shen HY, Zhang BP, Shin JH, Lei D, Du Y, Gao X, Wang Q, Ohlemiller KK, Piccirillo J, Bao JX (2007) Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss. Hear Res. 226: 52–60

122.Sun L, Ma K, Wang H, Xiao F, Gao Y, Zhang W, Wang K, Gao X, Ip N and Wu Z (2007) JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts. J Cell Biol. 179: 129-138

123.Sha HB, Xu J, Tang J, Ding J, Gong JF, Ge XM, Kong D, *Gao X. (2007) Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity and type 2 diabetes in mice. Physiological Genomics, 31:252-63

124.Qi X, Yang G, Yang L, Lan Y, Weng T, Wang J, Wu Z, Xu J, *Gao X, *Yang X. (2007) Essential role of Smad4 in maintaining cardiomyocyte proliferation during murine embryonic heart development. Dev Biol, 311:136-46

125.Zeng H, Di L, Fu GP, Chen YH, Gao X, Xu L, Lin X, Wen RR (2007) Phosphorylation of Bcl10 negatively regulates T cell receptor-mediated NF-κB activation. Mol Cell Biol, 27:5235-45

126.Fan, Y., Wang, W., Zhu, M., Zhou, J., Peng, J., Xu, L., Hua, Z., Gao X, Wang, Y. (2007) Analysis of hMLH1 missense mutations in East Asian patients with suspected hereditary nonpolyposis colorectal cancer. Clinical Cancer Research 13 : 7515-7521

127.Yang, Y., Zheng, J., Zhou, X., Yang, Z., Tan, Y., Liu, A., Gao, X., Chang Z, Sheng, H.Z. (2007) Potential treatment of liver-related disorders with in vitro expanded human liver precursors. Differentiation 75 : 928-938

128.Liu X, Chen Y, Zhang F, Chen L, Ha T, Gao X, Li C. (2007) Synergistically therapeutic effects of VEGF165 and angiopoietin-1 on ischemic rat myocardium. Scand Cardiovasc J. 41:95-101

129.Hua F, Ha T, Ma J, Li Y, Kelley J, Gao X, Browder IW, Kao RL, Williams DL, Li C (2007) Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism. J Immunol, 178:7317-24.

130.Liu L, Zhang X, Qian B, Min X, Gao X, Li C, Cheng Y, Huang J (2007) Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice. Eur J Heart Fail, 9:762-9

131.Tan X, Weng T, Zhang J, Wang J, Li W, Wan H, Lan Y, Cheng X, Hou N, Liu H, Ding J, Lin F, Yang R, Gao X, Chen D, Yang X（2007）Smad4 is required for maintaining normal murine postnatal bone homeostasis. J Cell Sci, 120: 2162-2170

132.Chen JY, Schopf JW, Bottjer DJ, Zhang CY, Kudryavtsev AB, Tripathi AB, Wang XQ, Yang YH, Gao X, Yang Y (2007) Raman spectra of a Lower Cambrian ctenophore embryo from southwestern Shaanxi, China. PNAS? 104: 6289-6292

133.Zhang D, Zhang F, Zhang Y, Gao X, Li C, Yang N, Cao K (2007) Combining erythropoietin infusion with intramyocardial delivery of bone marrow cells is more effective for cardiac repair. Transpl Int. 20:174-83

134.Zhang D, Zhang F, Zhang Y, Gao X, Li C, Ma W,Cao K.(2007) Erythropoietin enhances the angiogenic potency of autologous bone marrow stromal cells in a rat model of myocardial Infarction. Cardiology. 108:228-236

135.Fan Y, Liu X, Zhang H, Dai J, Zhang X, Zhu M, Gao X, Wang Y (2006) Variations in exon 7 of the MSH2 gene and susceptibility to gastrointestinal cancer in a Chinese population. Cancer Genet Cytogenet. 170:121-8

136.Gu X, Xu F, Song W, Yang Y, Hu P, Wang X, Gao X, Zhao Q (2006) A novel cytochrome P450, zebrafish Cyp26D1, involved in metabolism of all-trans retinoic acid, Molecular Endocrinology, 20:1661-72

137.Chen JY, Bottjer DJ, Davidson EH, Dornbos SQ, Gao X,Li CW, Yang YH, Li G, Wang XQ, Xian DC, Wu RH, Hwu YK (2006) Phosphatized polar-lobe-forming embryos from the Precambrian of southwest China. Science, 312: 1644-1646

138.Yu M, Sha H, Gao Y, Zeng H, Zhu M, Gao X* (2006) Alternative3’UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression. Biochem Biophys Res Commun. 345:479-85

139.Yang CX, Chen HQ, Chen C, Yu WP, Zhang WC, Peng YJ, He WQ, Wei DM, Gao X, Zhu MS (2006) Microfilament-binding properties of N-terminal extension of the isoform of smooth muscle long myosin light chain kinase. Cell Res, 16:367-76

140.Zhu Y, Zeng H, Gao X, Lu ZH (2006) Quantitative analysis of EcoR1 methylase-DNA complex by atomic force microscopy. Scanning 28: 15-19

141.Ha T, Li Y, Gao X, McMullen JR, Shioi T, Izumo S, Kelley JL, Zhao A, Haddad GE, Williams DL, Browder IW, Kao RL, Li C. (2005) Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkB activation in vivo.? Free Radical Biology & Medicine, 39:1570-80

142.Hua F, Ha T, Ma J, Gao X, Kelley J, Williams DL, Browder IW, Kao RL, Li C.(2005) Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts. Biochem Biophys Res Commun. 338:1118-25

143.Ha T, Hua F, Li Y, Ma J, Gao X, Kelley J, Zhao A, Haddad GE, Williams DL, Browder IW, Kao RL, Li C. (2005) Blockade of MyD88 Attenuates Cardiac Hypertrophy and Decreases Cardiac Myocyte Apoptosis in Pressure Overload Induced Cardiac Hypertrophy in vivo. Am J Physiol Heart Circ Physiol., 290(3):H985-94

144.Ha T, Li Y, Hua F, Ma J, Gao X, Kelley J, Zhao A, Haddad GE, Williams DL, William Browder I, Kao RL, Li C. (2005) Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res. 68:224-34.

145.Gu X, Xu F, Wang X, Gao X, Zhao Q. (2005) Molecular cloning and expression of a novel CYP26 gene (cyp26d1) during zebrafish early development. Gene Expr Patterns 5:733-9

146.Yang G, Cui F, Hou N, Chen X, Zhang J, Wang Y, Jiang N, Gao X, Yang X (2005) Transgenic mice that express Cre recombinase in differentiated hypertrophic chondrocytes, Genesis, 42:33-6

147.Ruan H, Zhang N, *Gao X (2005) Identification of a novel point mutation of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea (ENU) mutagenesis. Genetics, 169:819-31

148.Zhou L, Ma W, Yang Z, Zhang F, Lu L, Ding Z, Ding B, Ha T, *Gao X, *Li C. (2005)　VEGF(165) and angiopoietin-1 decreased myocardium infarct size through phosphatidylinositol-3 kinase and Bcl-2 pathways. Gene Ther. 12:196-202

149.Wu X, Zeng H, Zhang X, Zhao Y, Sha H, *Gao X, *Xu Q. (2004) PRL-3 promotes motility and metastasis of mouse melanoma cells.? Am J. Path. 164: 2039

150.Wen C, Xue B, Qin X, Yu M, Zhang M, Zhao D, Gao X, Gu J, Li C. (2004) hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation. FEBS Lett. 564: 171

151.Li C, Ha T, Gao X, Kelley J, Browder W, Williams DL. (2004) NF?B activation is required for the development of cardiac hypertrophy in vivo. Am J Phys: Heart and Circulatory Physiology. 287 : H1712

152.Li C, Ha T, Kelley J, Gao X, Qiu Y, Kao RL, Browder W, Williams DL. (2004) Modulating Toll-like receptor mediated signaling by (1-->3)-beta-d-glucan rapidly induces cardioprotection. Cardiovasc Res. 61:538

153.Zhu Y, Zheng H, Xie JM, Ba L, Gao X, Lu Z (2004) AFM studies on DNA structural changes induced by vincristine sulfate and aspirin. Microscopy and Microanalysis 10:286

154.Zhang F, Yang Z, Chen Y, Qin J, Zhu T, Xu D, Xu Z, Xu Q, Qian Y, Ma W, Chen L, Gao X, Li C, Ha T, Kao RL. (2003) Clinical cellular cardiomyoplasty: technical considerations.?J Card Surg.18:268

155.He F, Wang Z, Zhao J, Bao J, Ding J, Ruan H, Xie Q, Zhang Z, *Gao X. (2003) Large- scale screening of disease model through ENU mutagenesis in mice. Chinese Science Bulletin. 24:2665

156.Kao RL, Zhang FM, Yiang ZJ, Gao X, Li CF (2003) Cellular cardiomyoplasty using autologous satellite cells: from experimental to clinical study. Basic Appl. Myol. 13:1

157.Zhang F, Chen Y, Yang Z, Gao X, Ma W, Li C, Kao RL (2003) Cellular cardiomyoplasty for a patient with heart failure. Cardiovascular Radiation Medicine 4: 43

158.Zhang F, Gao X, Yiang ZJ, Ma W, Li C, Kao RL (2003) Cellular cardiomyoplasty: A preliminary clinical report. Cardiovascular Radiation Medicine 4: 39

159.Jiang P, Chen L, Liu J, Ding J, Gao X and Guo ZJ (2002) Novel zinc fluorescent probe bearing dansyl and aminoquinoline groups. Chemical Communication 2002:1424

160.Chen LZ and *Gao X (2002) Neuronal apoptosis induced by endoplasmic reticulum stress. Neurochemical Research, 27:891

161.McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, Herzlinger D, Weimaster G, Jiang R and Gridley T. (2001) Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development, 128:491 ?

162.Gao X, Gillig TA, Ye P, D’Ercole AJ, Matsushima GK and Popko B (2000) Interferon-gamma protects against Cuprizone-induced demyelination. ?Mol & Cell Neurosci. 16:338-49

163.Xue Y, Gao X (co-first author), Lindsell CE, Norton CR, Chang B, Hicks C, Gendron-Maguire M, Rand EB, Weinmaster G and Gridley T (1999) Embryonic Lethality and vascular defects in mice lacking the Notch ligand Jagged 1.? Hum Mol Genet 8:723-30

164.Gao X, Copeland NG, Gilbert DJ, Jenkins NA and Gridley T, (1998) Assignment of the murine Notch2 and Notch3 gense to chromosomes3 and 17. Genomics 49:60-1

165.Wubah JA,Ibrahim MM,Gao X, Pisano MM and Knudsen TB (1996) Teratogen-induced eye defect is mediated by p53-dependent embryonic apoptosis. Current Biology 6:60-9

166.Gao X, Knudsen TB, Ibrahim MM and Haldar S. (1995) Bcl-2 relieves deoxyadenylate stress and suppresses apoptosis in pre-B leukemia cells. Cell Death and Differentiation 2:69-77

167.Gao X,BlackburnMR and Knudsen TB. (1994) Activation of apoptosis by 2'-deoxyadenosine in mouse early postimplantation embryos. Teratology 49:1-12

168.BlackburnMR, Gao X, Airhart MJ, Skalko RG, Thompson LF, Knudsen TB. (1992) Adenosine levels in the postimplantation mouse uterus: quantitation by HPLC-fluorometric detection and spatiotemporal regulation by 5'-nucleotidase and adenosine deaminase. Dev Dyn. 194:155-68

169.Liu JN, Lu L, Gao X, Wang J, Zhu D, Lai LH, Xu XJ, Tang YQ. (1992) The structure basis of the poor fibrin specificity of urokinase (I)-knowledgebased prediction of Kringle structures of urokinase and its related proteins. SciChina, Series B, 35:176-82

170.郑一守, 秦国强, 高翔, 刘杰, 丁琪, 张梅芬, 姚建华 (1986)? 抗体形成细胞发育的免疫组织化学研究．实验生物学报，19 : 327—337

B.Books and reviews:

1. ? 高翔：小鼠ENU化学诱变和QTL分析在疾病研究中的应用，in 基因工程小鼠，p95-115，傅继梁主编，上海科学技术出版社

2. ? 高翔，迟慧梅：生命的起源与进化，p92-97；高翔：生物技术在医学中的应用，p118-126，in 生物医学导论，吴观陵主编，人民卫生出版社

3. ? Gao X, Kemper A and Popko B. (1999) Advanced transgenic and gene-targeting approaches. Neurochem. Res. 24:1181-8

4. ? 高翔（2007）：基因靶向改造技术的发展及其意义，生物化学与生物物理进展，34：1009-11

基金种类	基金项目名称
中国科学技术部	建立国家突变小鼠研究中心
中国科学技术部	通过ENU诱变大规模筛选突变小鼠
江苏省科技厅	用微阵列分析糖尿病小鼠肾脏的基因表达谱
中国科学技术部	几种小鼠疾病模型的表型分析
中国科学技术部	中国小鼠生物信息学数据库平台的建立
中国教育部	肿瘤转移中的PRL-3信号传导
中国自然科学基金	TLR信号在心脏肥大发育调节中的作用
中国教育部	基于血管分子生物学的药物发现和开发
中国科学技术部	先天性心脏病发生和筛选小鼠突变体
中国自然科学基金	杰出青年学者基金会
中国科学技术部	为疾病模型生成小鼠突变体
江苏省科技厅	中国突变小鼠资源中心创新研究
中国科学技术部	使用CRISPR / Cas9技术系统生成大鼠疾病模型
中国自然科学基金	用染色体置换研究野生小鼠基因组异质性
江苏省科技厅	开发用于药物研发的新型小鼠模型
中国科学技术部	为NRCMM建立无菌小鼠设施

Co-PI：

林兆宇

linzy@nicemice.cn

硕士生：

陈芊月

chenqy@nicemice.cn

郑尚

zhengshang@nicemice.cn

博士生：

邹达远

zoudy@nicemice.cn

王鼎玉

wangdy@nicemice.cn

王雨芳

wangyf@nicemice.cn

邹玉洁

zouyj@nicemice.cn

李旭

lixu@nicemice.cn

裴静文

peijw@nicemice.cn

刘其耀

liuqy@nicemice.cn

刘樾

liuyue@nicemice.cn

技术员：

邹家风

邹家香

毕业学生：

孔栋
沙海波
余明艳
贺芳
曾虎

阮海斌
顾星星
鲍洁
赵静
齐心

唐晶
葛晓梅
陈维倩
高艳
徐静悦

蒋璇
周玥
熊熙文
顾鹏宇
林兆宇

任凯群
严虹
李颖倩
黄赞
侯思源

冼黎
宋安营
唐安
王庆华
邹耩欢

蒋淑君
孙敏
史培良
赖贝贝
陈秦

高翔实验室

神经生物学

器官发育

代谢与免疫

干细胞及肿瘤生物学

友情链接：

Co-PI：
林兆宇 linzy@nicemice.cn
硕士生：
陈芊月 chenqy@nicemice.cn	郑尚 zhengshang@nicemice.cn
博士生：
邹达远 zoudy@nicemice.cn	王鼎玉 wangdy@nicemice.cn	王雨芳 wangyf@nicemice.cn
邹玉洁 zouyj@nicemice.cn	李旭 lixu@nicemice.cn	裴静文 peijw@nicemice.cn
刘其耀 liuqy@nicemice.cn	刘樾 liuyue@nicemice.cn
技术员：
邹家风	邹家香
毕业学生：

孔栋	沙海波	余明艳	贺芳	曾虎
阮海斌	顾星星	鲍洁	赵静	齐心
唐晶	葛晓梅	陈维倩	高艳	徐静悦
蒋璇	周玥	熊熙文	顾鹏宇	林兆宇
任凯群	严虹	李颖倩	黄赞	侯思源
冼黎	宋安营	唐安	王庆华	邹耩欢
蒋淑君	孙敏	史培良	赖贝贝	陈秦